| Judge James M. Rice | In 1849 was appointed by Governor Crittenden circuit judge, filled the office until the adoption of the new constitution, and in 1867 1868 |
| Judge George Newman Brown | 1880 - 1886 |
| Judge William C. Ireland | 1874-1880 |
| Judge John M. Burns | 1886-1892 |
| Judge Stephen Girard Kinner | 1892 - 1910 |
| Judge Clarence Halbert | 1916, 1921, & 1927 |
| Judge Henry L. Woods | 1924 - 1933 |
| Judge Marc I. Rosen | 2000 - 2009 |
| Judge C. David Hagerman | |
| Colonel Eldred E. Adams, Sr | 1954 - 1955 |
| Judge Daniel R. Sparks | 2000 - 2006 |
| Judge John E. Gardner | |
| Judge James A. Knight | 1980 - 1999 |
| Judge John David Preston | - Present |
| Judge Stephen Frazier | |
| Judge W. D. Sparks | 1956 - 1975 |
| Judge Watt M. Prichard | 1934 - 1958 |
| Judge Janie Carol Wells | - Present |
| Judge William B. Hazelrigg | 1977 - 1983 |
| Judge Archibald Borders | 1850 - 1858 - First Judge of Lawrence Co., KY |
| Judge Fred M. Vinson | March 4, 1933 – May 27, 1938 |
| Judge John McConnell Rice | 1883 and 1884; 1890 - 1898 upon his death |
| Judge John Melvin Hall | Served 4 years & United States Commissioner for Eastern Kentucky |
| Judge James W. Turner | 1946-1954 |
| Judge E. Poe Harris | 1957 - 1961 |
| Judge Chesley A. Lycan | 1961 - 1970 |
| Judge J.E.M. Robinson | 1966 - 1974 |
| Judge Charles Sinnette | 1973 - 1992 |
| Judge Kelley Asbury | 1979 - 2000 |
| Judge Marc I. Rosen | 2000 - 2009 |
| Judge C. David Hagerman | |
| Colonel Eldred E. Adams, Sr | 1954 - 1955 |
| Judge William Fanning | 1971 - 1979 |
| Judge Daniel R. Sparks | 2000 - 2006 |
| Judge Frederick Moore Vincent | |
| Judge J. F. Bailey | 1916 - 1945 |
| Judge Andrew Jackson Kirk | 1904 - 1915 |
| Judge Andrew Jackson Auxier | 1898 - 1903 |
| Judge John S. Patton | 1892 - 1897 |
| Judge Susan Mullins Johnson | |
| Judge John Kevin Holbrook | |